Membrane lipids hop in and out of rafts in the blink of an eye

March 23, 2017

New fluorescent lipids demonstrate how specialized regions in the cell membrane function



Top: Typical image sequences (every 33 milliseconds) of a raft domain undergoing signaling (green) and a sphingomyelin analog (red). The sphingomyelin analog molecule was associated with a signaling raft domain from frame 4 to 9 (orange arrows). Bottom: Schematic model showing the transient recruitment of sphingomyelins to various raft domains in the time scale of 10 to 50 milliseconds. The signaling raft itself was stable for up to several tens of minutes, working as a stable signaling platform.